This CDC webpage describes the “Overdose Data to Action in States” (OD2A) program, a cooperative agreement funding state health departments to enhance drug overdose surveillance and prevention efforts. It outlines the program’s focus on using data to inform evidence-based prevention strategies, particularly for communities disproportionately affected by the overdose epidemic. The page also details required and optional surveillance and prevention strategies, emphasizing harm reduction, health equity, and culturally relevant interventions.