Topic: Neonatal Abstinence Syndrome

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Healthy Pregnancy Healthy Baby Fact Sheets

This series of four fact sheets emphasizes the importance of continuing a mother’s treatment for opioid use disorder (OUD) throughout pregnancy. The series includes information on OUD and pregnancy, OUD treatment, neonatal abstinence syndrome, and considerations to address before hospital discharge.

Neonatal Abstinence Syndrome

Jansson, L. M., & Patrick, S. W. (2019). Neonatal Abstinence Syndrome. Pediatric clinics of North America, 66(2), 353–367. https://doi.org/10.1016/j.pcl.2018.12.006

Novel Technologies for Infants With Neonatal Opioid Withdrawal Syndrome

This article describes innovative technologies being developed to help infants with Neonatal Opioid Withdrawal Syndrome (NOWS), a condition affecting newborns exposed to opioids in utero. Two start-up companies, supported by the NIH HEAL Initiative, have created devices aimed at alleviating withdrawal symptoms in these infants: a vibrating bassinet pad and an ear-worn neurostimulation device. These devices have recently obtained FDA Breakthrough Device status, indicating a promising future for improved treatment options for NOWS.

Neonatal Abstinence Syndrome Family Guide / Toolkit (NAS)

The Pennsylvania Department of Health in partnership with the Northwestern Pennsylvania Neonatal Abstinence Syndrome Coalition and the Ohio Perinatal Quality Collaborative have created the NAS Family Guide Toolkit to help educate families and individuals about NAS, treatment options, and other supports. Neonatal Abstinence Syndrome (NAS) is a group of withdrawal symptoms in newborns that show up after being exposed to medications or substances, most often opioids, benzodiazepines and/or barbiturates during pregnancy.

Neonatal Opioid Withdrawal Syndrome

This website, from the Cleveland Clinic, provides comprehensive information on Neonatal Opioid Withdrawal Syndrome (formerly Neonatal Abstinence Syndrome), covering its causes, symptoms, diagnosis, treatment, prevention, and outlook.

Neonatal Abstinence Syndrome

Anbalagan S, Falkowitz DM, Mendez MD. Neonatal Abstinence Syndrome. [Updated 2024 Apr 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551498/

Reference Guide for Labor and Delivery Complicated By Substance Use

(Revised April 2021) Substance misuse, dependency, and substance use disorders (SUDs), including opioid use disorder (OUD), are prevalent among Nevada adult populations, including among individuals of reproductive age. Subsequently, OUD also occurs during pregnancy at an alarming rate with far reaching effects on both the parent and infant. SUD is a primary chronic disease similar to diabetes and hypertension, not a moral failure or character weakness, and should be treated as such by the medical professionals who care for pregnant patients and their infants. Currently, pregnant patients with SUD who present to Labor & Delivery (L&D) units, may receive significant variation in services. These differences include identification and treatment of SUD, identification and treatment for the infant(s), reproductive planning, and care coordination. Practice variance without the use of common generally accepted expert guidelines may potentially lead to parental and/or neonatal complications before, during, and/or after delivery. This reference guide aims to address some of these variances and provide a resource with best practices, guidelines, and protocols for medical professionals involved in the care of pregnant patients with OUD who are admitted to L&D units for delivery and their infants up until discharge.

Reference Guide for Reproductive Health Complicated by Substance Use

(Revised April 2021) Substance misuse, dependency, and substance use disorders (SUDs), including opioid use disorders (OUDs) are common among Nevada adult populations. These issues are also occurring during pregnancy at an alarming rate with far reaching effects on both mother and infant. To date, the single best strategy we have to identify and help those that want assistance is adding screening and referral to treatment, known as Screening, Brief Intervention and Referral to Treatment (SBIRT), into the clinical setting. Medical professionals are often the first line to aid in this effort. Note that this document uses the term “medical professional” to be inclusive of doctors and advanced practitioners. The intention for this guide is to provide basic directives for successfully implementing Screening, Brief Intervention and Referral to Treatment (SBIRT), into the clinical setting. SBIRT, specifically how to apply it to pregnant and non-pregnant persons of reproductive age populations.

Medications for Opioid Use Disorder During Pregnancy

This self-paced, online course offers an evidence based/informed review of buprenorphine vs methadone during pregnancy and recommendations for providers/organizations that treat pregnant, postpartum, and reproductive age patients.